International Journal of Clinical Research

Objective To study the age-specific distribution of anti-Mullerian hormone (AMH) in women undergoing routine gynecological examination in our institution, and to explore the relationship between AMH and follicle stimulating hormone (FSH) levels in different age groups. Methods A total of 427 women undergoing routine gynecological examination who visited the department of Obstetrics and Gynecology outpatient department of Hunan Provincial Peoples Hospital from June 2020 to June 2022 were selected as the subjects. They were divided into 6 groups by age: 18-25 years old group (77 cases), 26-30 years old group (68 cases), 31-35 years old group (53 cases), 36-40 years old group (70 cases), 41-45 years old group (83 cases), > 45 years old group (76 cases). The levels of AMH and FSH in serum were determined by iFlash3000 chemiluminescence analyzer, and the changes of AMH with age and the age-specific distribution of AMH and the relationship between AMH and FSH in these groups were analyzed. Results 1. The serum AMH level of 427 women undergoing routine gynecological examination in our institution decreased gradually with the increase of age, and the highest level was found in 18-25 years old group.The serum AMH level began to decrease significantly after 35 years old, and remained at a low level after 50 years old.Serum FSH level gradually increased with age, and increased significantly after 40 years old (P < 0.001). 2. Serum AMH level was negatively correlated with age in all groups (P < 0.01). 36-40 years old group, 41-45 years old group, & GT; There was a negative correlation between serum AMH level and FSH level in the 45-year-old group, with correlation coefficients of -0.19, -0.70 and -0.41 (P < 0.05), and there was a negative correlation between serum AMH level and FSH level in the 18-25 years old group, 26-30 years old group and 31-35 years old group, but there was no statistical significance. Conclusion Serum AMH levels in 427 women undergoing routine gynecological examination in our institution decreased with age, and began to decrease significantly after 35 years old, and remained at a lower level after 50 years old;The decline of AMH (after 35 years old) reflects the decline of ovarian reserve earlier than FSH (after 40 years old);.There was a negative correlation between Serum AMH levels and serum FSH levels in older women (>35 years old) Both AMH and FSH can be used to reflect ovarian reserve function, which can be combined with AMH and FSH to predict ovarian reserve in clinical practice and provide guidance for clinical work.

Antimullerian hormone; Follicle stimulating hormone; Age; Ovarian reserve