Comment on: An Expanded View of Complex Traits: From Polygenic to Omnigenic-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Comment on: An Expanded View of Complex Traits: From Polygenic to Omnigenic

Comment on: An Expanded View of Complex Traits: From Polygenic to Omnigenic

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DOI	10.20900/jpbs.20170014S2
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2017, 2(5)
作者	Xin.He*,
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Abstract	The recent paper by Pritchard and colleagues proposed an “omnigenic” model to explain genetic architecture of complex human traits. The model states that a trait may be directly affected by a small set of “core genes”, but many other genes may perturb the activity of the core genes because of the inter-connectivity of biological networks. I believe this is an extremely important paper.
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2.Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013; 45(10): 1238-1243.r

3.He X, Fuller CK, Song Y, Meng Q, Zhang B, Yang X, Li H. Sherlock: detecting gene-disease associations by matching patterns of expression QTL and GWAS. Am J Hum Genet. 2013; 92(5): 667-680.r

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Xin.He*. Comment on: An Expanded View of Complex Traits: From Polygenic to Omnigenic, Journal of Psychiatry and Brain Science. 2017; 2; (5). https://doi.org/10.20900/jpbs.20170014S2.

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