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Omnigenic Model: The Evidence from Neurodegenerative Diseases

Omnigenic Model: The Evidence from Neurodegenerative Diseases

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DOI	10.20900/jpbs.20170019
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2017, 2(6)
作者	Libing.Shen*,Qili.Shi,
作者单位	Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Abstract	Recently, a seminal model, called the omnigenic model, is proposed for understanding complex traits such as schizophrenia. In this study, we examined this model in Alzheimer’s disease and Parkinson’s disease from the perspectives of expression spectrum, shared disease-associated genes, common biological pathways, organ specificities, and network properties. Our results support the arguments brought forward by the omnigenic model. Although we only provided the limited evidence for the omnigenic model in neurodegenerative diseases, we hope that our effort can improve the understanding of these diseases and thus spur new ideas on how to prevent and treat them. The most important information we try to convey in our study is that there are more genes than we expected playing a role in the pathogenesis of neurodegenerative diseases and it is insufficient to study these diseases only focusing on some core genes or genetic pathways.
KeyWord	Omnigenic model;Neurodegenerative diseases; Alzheimers disease; Parkinsons disease
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引用本文

Libing.Shen*,Qili.Shi. Omnigenic Model: The Evidence from Neurodegenerative Diseases, Journal of Psychiatry and Brain Science. 2017; 2; (6). https://doi.org/10.20900/jpbs.20170019.

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