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ROS-Induced DNA Damage as an Underlying Cause of Aging

ROS-Induced DNA Damage as an Underlying Cause of Aging

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DOI	10.20900/agmr20200024
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2020, 2(4)
作者	Gabriel Robert,J. Richard Wagner*,
作者单位	Département de médecine nucléaire et radiobiologie Faculté de médecine et des sciences de la santé, Université de Sherbrooke, J1H 5N4, Sherbrooke, Canada ;
Abstract	Oxidative or redox stress arises from the generation of reactive oxygen species (ROS) as a by-product of oxygen utilization. ROS-mediated damage to DNA accumulates over time and leads to irreversible changes in cellular functions and integrity associated with aging phenotypes. Here, we discuss the contribution of ROS-induced DNA damage to aging and the important role of deficiencies in DNA repair pathways that counteract this damage. We elaborate on the relationship of aging with mutagenesis and epigenetics and conclude with promising avenues to prevent aging.
KeyWord	reactive oxygen species; redox stress; DNA damage; DNA repair; mutagenesis; epigenetics; antiaging therapies
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Gabriel Robert,J. Richard Wagner*. ROS-Induced DNA Damage as an Underlying Cause of Aging, Advances in Geriatric Medicine and Research. 2020; 2; (4). https://doi.org/10.20900/agmr20200024.

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