AGMR

Understanding the role of genetic factors in non-Mendelian traits characteristic for post-reproductive life, herein referred to as age-related traits, is lagged behind the understanding of the genetic architecture of Mendelian traits. This lag calls for new, more comprehensive approaches in the analyses of age-related traits leveraging their characteristic features. This paper discusses the role of the inherent heterogeneity in genetic predisposition to age-related traits and pleiotropy. It shows that the comprehensive analyses leveraging such heterogeneity can substantially increase the efficiency and accelerate the progress in uncovering genetic predisposition to such traits.

genetic association studies; age-related traits; aging; pleiotropy