Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies

Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies

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DOI	10.20900/jpbs.20210009
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2021, 6(3)
作者	Xianjin Zhou*,
作者单位	Department of Psychiatry, University of California San Diego, La Jolla, 92093, California, USA ;
Abstract	Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future.
KeyWord	cognitive impairment; anti-NMDAR1 autoantibodies; antigenic epitope
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1.Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148(10):1301-8.

2.Singh T, Neale MN, Daly MJ. Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia. MedRxiv: 20192815
[Preprint]. 2020 Sep 18.

3.Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7(12):1091-8.

4.Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10(1):63-74.

5.Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry. 2014;19(10):1143-9.

6.Schou M, Saether SG, Borowski K, Teegen B, Kondziella D, Stoecker W, et al. Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care. Psychol Med. 2016;46(16):3303-13.

7.Steiner J, Teegen B, Schiltz K, Bernstein HG, Stoecker W, Bogerts B. Prevalence of N-methyl-D-aspartate receptor autoantibodies in the peripheral blood: healthy control samples revisited. JAMA Psychiatry. 2014;71(7):838-9.

8.Castillo-Gomez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, et al. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry. 2017;22(12):1776-84.

9.Wang Q, Delva L, Weinreb PH, Pepinsky RB, Graham D, Veizaj E, et al. Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration. Fluids Barriers CNS. 2018;15(1):10.

10.St-Amour I, Pare I, Alata W, Coulombe K, Ringuette-Goulet C, Drouin-Ouellet J, et al. Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier. J Cereb Blood Flow Metab. 2013;33(12):1983-92.

11.Fossan GO. The transfer of IgG from serum to CSF, evaluated by means of a naturally occurring antibody. Eur Neurol. 1977;15(4):231-6.

12.Zhou X. A novel one-step quick assay for detection of SARS-CoV2 antibodies across mammalian species. PeerJ. 2021;9:e11381.

13.Yue W, Caldwell, S, Risbrough V, Powell S, Zhou X. Chronic Presence of Blood Circulating Anti-NMDAR1 Autoantibodies Impairs Cognitive Function in Mice. bioRxiv: 440976
[Preprint]. 2021 Apr 22.

14.Foster TC. Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity. Prog Neurobiol. 2012;96(3):283-303.

15.Kumar A, Foster TC. Linking redox regulation of NMDAR synaptic function to cognitive decline during aging. J Neurosci. 2013;33(40):15710-5.

16.Chan K, Nestor J, Huerta TS, Certain N, Moody G, Kowal C, et al. Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory. Nat Commun. 2020;11(1):1403.

17.Jones BE, Tovar KR, Goehring A, Jalali-Yazdi F, Okada NJ, Gouaux E, et al. Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors. Sci Transl Med. 2019;11(500):eaaw0044..

18.Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, et al. Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model. Mol Psychiatry. 2019;24(10):1489-501.

引用本文

Xianjin Zhou*. Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies, Journal of Psychiatry and Brain Science. 2021; 6; (3). https://doi.org/10.20900/jpbs.20210009.

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