Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies

Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies

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DOI	10.20900/jpbs.20210009
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2021, 6(3)
作者	Xianjin Zhou*,
作者单位	Department of Psychiatry, University of California San Diego, La Jolla, 92093, California, USA ;
Abstract	Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future.
KeyWord	cognitive impairment; anti-NMDAR1 autoantibodies; antigenic epitope
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Xianjin Zhou*. Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies, Journal of Psychiatry and Brain Science. 2021; 6; (3). https://doi.org/10.20900/jpbs.20210009.

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