The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions

The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions

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DOI	10.20900/agmr20210019
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2021, 3(4)
作者	Donna M. Poscablo,E. Camilla Forsberg*,
作者单位	Institute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA ; Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA ;
Abstract	Platelets provide life-saving functions by halting external and internal bleeding. There is also a dark side to platelet biology, however. Recent reports provide evidence for increased platelet reactivity during aging of mice and humans, making platelets main suspects in the most prevalent aging-related human pathologies, including cardiovascular diseases, stroke, and cancer. What drives this platelet hyperreactivity during aging? Here, we discuss how hematopoietic stem cell differentiation pathways into the platelet lineage offer avenues to understand the fundamental differences between young and old platelets. Recent advances begin to unravel how the cellular and molecular regulation of the parent hematopoietic stem and progenitor cells likely imbue aging characteristics on the resulting Plt progeny. The resulting mechanistic insights into intrinsic platelet reactivity will provide strategies for selectively targeting age-related pathways. This brief viewpoint focuses on current concepts on aging hematopoiesis and the implications for platelet hyperactivity during aging.
KeyWord	platelets; aging; hematopoietic stem cells; megakaryocyte progenitor cells; hematopoiesis; platelet hyperactivity
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Donna M. Poscablo,E. Camilla Forsberg*. The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions, Advances in Geriatric Medicine and Research. 2021; 3; (4). https://doi.org/10.20900/agmr20210019.

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