International Journal of Medicine and Data

Objective To investigate the expression of LRG1 in breast cancer tissues and its effect on invasion and migration of MCF-7 cells. Methods 50 patients with breast cancer from January 2022 to December 2022 were selected as the research objects. Immunohistochemistry and immunofluorescence staining were used to observe the expression of LRG1 in breast tissue, and the effect of LRG1 on inhibiting the invasion and migration of MCF-7 cells was studied. Results LRG1 expression was found in all 50 breast cancer tissues, and low expression was found in only 1 paracancer tissue, the data difference was significant (P < 0.05). The invasion and migration ability of MCF-7 cells expressed by LRG1 were decreased. Conclusion The high expression of LRG1 tissue in breast cancer is closely related to the severity of disease and metastasis of patients. Reducing LRG1 can reduce the invasion and migration ability of MCF-7 cells, which can provide scientific guidance for clinical disease treatment.

LRG1 expression; Breast cancer tissue; MCF-7; Cell invasion; migration