International Journal of Genetics Frontiers

Objective To explore the correlation between tumor susceptibility marker cytochrome cytochrome P4501A1 and lung cancer. Method In this study, a total of 60 patients with primary lung cancer were selected, and 60 control subjects were selected. The time period of the experiment was set from April 2021 to June 2022. After all the patients were admitted to the hospital, medical staff extracted DNA from their blood and applied multiple polymerase chain reaction-restriction fragment length polymorphism to test their cytochrome P4501A1 to determine the genotype protection characteristics of the patients. Results The results of this study showed that the occurrence of squamous cell carcinoma was significantly associated with the mutation of cytochrome P4501A1 (OR=2.76, P=0.011), and the combined effect of smoking and cytochrome P4501A1 was not found to be associated with different types of lung cancer are closely related. For non-smoking patients, cytochrome P4501A1 heterozygosity may be a very important protective factor (OR=0.16, P=0.033), which can reduce the risk of phosphorus cancer to a certain extent. The combined effects of alcohol consumption and cytochrome P4501A1 mutant gene are closely related to squamous cell carcinoma (OR=4.33, P=0.046). However, the combined effect of cytochrome P4501A1 heterozygous gene was closely related to adenocarcinoma (OR=22.01, P=0.007). Conclusion The results of this study show that cytochrome P4501A1 mutation and genotype are an important susceptibility factor for lung cancer. Relevant researchers can determine whether a patient has a high risk of lung cancer through genetic diagnosis. For the follow-up treatment of patients and daily life In terms of management, it has a very positive guiding role, which cannot be ignored in terms of improving the health of the population.

cytochrome; cytochrome P4501A1; lung cancer; case-control analysis