| Abstract |
Objective To investigate the therapeutic effect of Tongxinluo capsule on elderly patients with cerebral vascular stenosis and cerebral infarction and its influence on the expression of ox-LDL and LP-PLA2 in serum. Methods A total of 106 elderly patients with cerebral vascular stenosis and cerebral infarction admitted to the geriatric department of our hospital from May 2019 to May 2020 were selected as the research objective. According to the random number table method, they were divided into the control group and the observation group, with 53 patients in each group. The control group was given conventional therapy, and the observation group was given Tongxinluo capsule on the basis of the control group.After 2 months of treatment, the two groups of patients featured by their phospholipic acid level, serum adiponectin, carotid artery intima thickness (CIMT), Platelet activity index (including Platelet particle membrane protein-140, GMP-140), thromboalkane B2,TXB2), platelet activating factor (platelet activating factor, PAF) and platelet aggregation rate), serum oxidized low density lipoprotein (oxidized low density lipoprotein, ox - LDL), lipoprotein associated phospholipase A2 (lipoprotein associated phospholipase A2, Lp - PLA2) to compare treatment effects and the patients quality of life, and to observe the adverse reaction. Results Two groups of patients before treatment, phosphatidic acid, serum adiponectin levels and CIMT there was no significant difference (P>0.05), and two groups of patients after treatment, phosphatidic acid, serum adiponectin levels and CIMT were significantly improved, and the serum phosphatidic acid, CIMT observation group was obviously lower than the control group (P<0.05), adiponectin level is significantly higher than the control group (P<0.05), the difference was statistically significant.Before treatment, there was no significant difference in platelet activity indexes between the two groups (P>0.05), while after treatment, the platelet activity indexes of gmp-140, TXB2, PAF and platelet agglutination rate of the two groups were significantly improved, and the platelet activity of the observation group was significantly lower than that of the control group (P<0.05), with statistically significant differences.Before treatment, there was no significant difference in serum ox-LDL and Lp-PLA2 levels between the two groups (P>0.05), while after treatment, the serum ox-LDL and Lp-PLA2 levels of the two groups were significantly reduced (P<0.05), and the difference was statistically significant in the observation group compared with the control group (P<0.05).Before treatment, there was no significant difference in the quality of life scores between the two groups (P>0.05), but after treatment, the quality of life of the two groups was significantly improved, and the observation group was significantly higher than the control group (P<0.05), the difference was statistically significant.After treatment, the effective rate in the observation group(92.45%) was significantly higher than that in the control group(77.36%), and the incidence of adverse reactions (7.55%) was significantly lower than that in the control group (16.98%). Conclusion Tongxinluo capsule can protect nerve function, reduce inflammation, and reduce tissue damage caused by cerebral infarction, so as to reduce serum ox-LDL and LP-PLA2 levels in elderly patients with cerebral stenosis with cerebral infarction, and improve the quality of life of the patients, with significant effect and good safety.
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