International Journal of Medicine and Data

Objective To analyze the feasibility and practicability of elastic fiber special staining in the pathological diagnosis of colorectal cancer. Methods 80 colorectal cancer patients received from November 2020 to June 2022 were included in the study, and randomly divided into experimental group and reference group, with 40 patients in each group. Pathological diagnosis was adopted in both groups. In the reference group, HE and CD31/CD34 immunohistochemistry were performed, and in the experimental group, HE and elastic fiber special staining were performed. TNM staging, diagnostic positive rate and prognosis were compared between the two groups. Results The proportion of T4, N1, N2 and M1 in the experimental group was higher than that in the reference group, while the proportion of N0 in the experimental group was lower than that in the reference group, with statistical difference (P<0.05); The positive rate of diagnosis in the experimental group was higher than that in the control group (P; In the experimental group, there were 16 cases of elastic membrane invasion and 24 cases of elastic membrane non invasion. The postoperative recurrence index, liver and peritoneal metastasis index of the non invasion group were lower than those of the control group, with statistical difference (P<0.05). Conclusion Elastic fiber special staining is feasible in the pathological diagnosis of colorectal cancer. Compared with routine HE staining and CD31/CD34 immunohistochemistry, it has higher positive rate, more accurate clinical staging, and is helpful to evaluate the prognosis.

elastic fiber special dyeing; Colorectal cancer; Pathological diagnosis; The feasibility of