International Journal of Medicine and Data

The production technology of hydroxycamptothecin freeze-dried powder for injection was studied in this paper. In the course of the research, the main function and research status of hydroxycamptothecin were introduced briefly. At the same time, in the current social development background, is also stepping up the hydroxycamptothecin freeze-dried powder production process research. In this paper, the preparation technology, quality standard and stability research measures of hydroxycamptothecin freeze-dried powder for injection were put forward. In the course of this study, it was found that the chemical property of hydroxycamptothecin freeze-dried powder was not stable enough. It was found that the stability of hydroxycamptothecin lyophilized powder could be improved by optimizing the process, which included preparation of coating, dissolution process, pharmacokinetic test and drug property study. Finally, it was found that the properties of hydroxycamptothecin freeze-dried powder were affected by light intensity and high temperature. Under the above two conditions, the shape and relative content of hydroxycamptothecin freeze-dried powder were affected by high temperature, while the effect of light intensity on the relative content of hydroxycamptothecin freeze-dried powder was only relative, therefore, judging temperature is the main.

hydroxycamptothecin; Freeze dried powder injection; Production process