通过靶向小胶质细胞极化干预阿尔兹海默症的药物开发-国际医药研究前沿-CSCIED科技核心评价数据库-手机版

通过靶向小胶质细胞极化干预阿尔兹海默症的药物开发

Drug discovery in Alzheimers Disease by targeting microglia polarization

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DOI	10.12208/j.imrf.20220193
刊名	国际医药研究前沿 International Medical Research Frontier
年，卷(期)	2022, 6(6)
作者	程倩*,徐翀,司马健,
作者单位	中国药科大学江苏南京 ;
摘要	随着社会老龄化的加剧，阿尔兹海默症患者数量呈快速上升的趋势。阿尔兹海默症是一种中枢神经系统退行性疾病，患者往往伴随着渐进性的认知功能障碍。在阿尔兹海默症的发生与发展中，小胶质细胞会被激活并发挥重要作用。在疾病发生中，激活的小胶质细胞通常会极化为促炎的M1和抗炎的M2两种表型。本文阐述了小胶质细胞的特点及功能，并介绍了通过靶向小胶质细胞极化从而干预阿尔兹海默症的策略。
Abstract	With the aging of society, the number of patients with Alzheimers disease (AD) is rapidly increasing. AD is a degenerative disease of the central nervous system, often accompanied by progressive cognitive dysfunction. Microglia are activated and exert crucial function during the pathogenesis of AD. Activated microglial cells are polarized into distinct M1 or M2 phenotype, each play pro-inflammatory or anti-inflammatory function respectively. This review summarizes the feature and function of microglia and introduces the strategies of targeting microglia polarization to intervene AD.
关键词	小胶质细胞；阿尔兹海默症；神经炎症
KeyWord	Microglia; Alzheimers Disease; Neuroinflammation
基金项目
页码	4-8

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引用本文

程倩*,徐翀,司马健. 通过靶向小胶质细胞极化干预阿尔兹海默症的药物开发 [J]. 国际医药研究前沿. 2022; 6; (6). 4 - 8.

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