International Journal of Clinical Research

Objective: To explore the surgical approach of radiofrequency ablation for hepatocellular carcinoma. Methods A total of 1284 patients with hepatocellular carcinoma undergoing radiofrequency ablation in department of Hepatobiliary Surgery of Yuhuangding Hospital of Yantai from January 2015 to November 2020 were analyzed and summarized. They were divided into percutaneous, laparoscopic and open surgery groups according to surgical approaches. The operative time, intraoperative blood loss, length of hospital stay, postoperative liver function, postoperative AFP changes, and surgical complications were compared. SPSS20.0 was used for statistical analysis. Results The average follow-up was 44±32 months. There were no significant differences in postoperative liver function changes (P>0.05), surgery-related complications(P>0.05) and tumor recurrence(P>0.05) among the three approaches. The level of AFP decreased significantly after operation, and there were no surgical deaths in three groups. However, the duration of percutaneous ablation (t=34.312, P<0.05) and length of hospital stay (t=14.608, P<0.05) were significantly shorter than those of laparoscopic and open surgery. Conclusion Percutaneous, laparoscopic and open radiofrequency ablation for hepatocellular carcinoma are safe and effective, and the time of percutaneous ablation is shorter, so the surgical approach should be selected according to the specific location of the patients tumor.

Liver cancer; Radiofrequency ablation; Treatment approach; Individualized