长链非编码RNA CCAT2与癌症-CSCIED科技核心评价数据库-手机版

长链非编码RNA CCAT2与癌症

Long non-coding RNA CCAT2 and cancer

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DOI
刊名	生命科学
年，卷(期)	2018, 30(11)
作者	莫娇1,2李子涵1于水灵1,2夏磊1,2杨玉容1,2谢伟全1涂剑1,
作者单位	1.南华大学药物药理研究所2.南华大学医学研究中心
摘要	长链非编码RNA (lncRNA)与癌症的发生发展密切相关。结肠癌相关转录因子(CCAT) 2是2013年鉴定的一种新的lncRNA,已发现其在结直肠癌、肝癌、乳腺癌以及胃癌等多种癌细胞中表达异常升高,通过Wnt、PI3K/AKT/m TOR和GSK3β/β-catenin等信号通路形成复杂的癌症调控网络,在癌症的增殖、侵袭/转移和细胞凋亡等过程中发挥着重要的作用,提示CCAT2有望成为癌症诊断与治疗的新的分子靶点。现综合近年来CCAT2在癌症中的研究进展作一综述。
Abstract	Long non-coding RNA (lncRNA) has close relationship with the development of human cancer.Colon cancer associated transcription factor (CCAT) 2, a newly identified member of many lncRNAs in 2013, has been found to be up-regulated in various cancers such as colorectal, liver, breast and gastric cancer.It not only develops a complicated network of cancer controlled under the signaling pathways like Wnt, PI3 K/AKT/mTOR and GSK3β/β-catenin, but also plays an important role in cell proliferation, invasion/metastasis and cell apoptosis.All above suggests CCAT2 could be expected to become a new target for the diagnosis and treatment of cancer.Therefore, this paper summarizes the research progress of CCAT2 with cancer in recent years.
关键词	长链非编码RNA;结肠癌相关转录因子2;癌症;
KeyWord	long non-coding RNA (lncRNA);colon cancer associated transcription factor (CCAT) 2;cancer
基金项目
页码	1252-1257

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引用本文

莫娇,李子涵于水灵,夏磊,杨玉容,谢伟全涂剑. 长链非编码RNA CCAT2与癌症 [J]. 生命科学. 2018; 30; (11). 1252 - 1257.

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