m6A去甲基化酶ALKBH5——新的原癌基因-CSCIED科技核心评价数据库-手机版

m6A去甲基化酶ALKBH5——新的原癌基因

ALKBH5, a kind of m6A demethylase, a new proto-oncogene

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DOI
刊名	生命的化学
年，卷(期)	2022, 42(09)
作者	袁敏1,2周志刚3杨萍2陈灵瑶1侯琳2翁若兰2涂剑1,
作者单位	1.桂林医学院药学院2.桂林医学院附属医院广西肝脏损伤与修复分子医学重点实验室3.桂林医学院第二附属医院
摘要	AlkB同源蛋白5（AlkB homolog 5,ALKBH5）属于AlkB家族，对N6-甲基腺苷（N6-methyladenosine,m6A）具有高效的脱甲基活性，参与RNA的剪接、加工、出核和翻译等生物学过程。近年来研究发现，ALKBH5在卵巢癌、胃癌、肺癌和胶质母细胞瘤等生殖、消化、呼吸和神经系统恶性肿瘤中的表达异常升高，而且这种异常高表达往往密切关联癌细胞增殖、侵袭/迁移与耐药，预示ALKBH5可能成为一种新的原癌基因。因此，本文主要就ALKBH5在这些系统癌症中的促进作用及其机制作一综述，旨在明确新的癌症防治靶点并研发新药。
Abstract	AlkB homologue 5(ALKBH5), belonging to the AlkB family, has efficient demethylation activity on N6-methyladenosine(m6A) involved in the biological processes such as RNA splicing, processing, nuclear exporting, translating, and etc. Recent studies have found that ALKBH5 expression is abnormally elevated in the cancers from reproductive, digestive, respiratory and nervous systems such as ovarian, gastric, lung cancer,glioblastoma, and so on. Furthermore, the high expression often affects the cell proliferation, invasion/migration of cancer, and closely related with drug resistance. All above, ALKBH5 might become another new proto-oncogene. Therefore, this paper mainly reviews the promoting role and mechanism of ALKBH5 in these systemic cancers, aiming to identify new targets for clinical treatment and prevention of cancer and develop new drugs.
关键词	m6A;去甲基化酶;AlkB同源蛋白5;原癌基因;
KeyWord	m A ;demethylase;AlkB homolog 5;proto-oncogene
基金项目
页码	1722-1728

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引用本文

袁敏,周志刚杨萍陈灵瑶侯琳翁若兰涂剑. m6A去甲基化酶ALKBH5——新的原癌基因 [J]. 生命的化学. 2022; 42; (09). 1722 - 1728.

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