亲环素A生物学功能的研究进展-CSCIED科技核心评价数据库-手机版

亲环素A生物学功能的研究进展

Research Progress on the Biological Functions of Cyclophilin A

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DOI
刊名	中国动脉硬化杂志
年，卷(期)	2005, (02)
作者	涂剑,严鹏科,廖端芳,
作者单位	南华大学药物药理研究所,南华大学药物药理研究所,南华大学药物药理研究所
摘要	亲环素A是一种在生物界广泛存在、高度保守的蛋白质,具有肽基脯氨酰顺/反异构酶活性,参与蛋白质折叠、装配与运输;它在细胞内能与环孢酶素A结合,参与免疫抑制;还可介导胆固醇转运,能发挥前炎性因子的功能,并且在信号转导中具有重要作用。
Abstract	Cyclophilin A is a highly conserved protein widely present in the biological world. It possesses peptidyl-prolyl cis/trans isomerase activity and is involved in protein folding, assembly, and transport. Within cells, it can bind to cyclosporin A and participate in immunosuppression. Additionally, it mediates cholesterol transport, functions as a pro-inflammatory factor, and plays a significant role in signal transduction.
关键词	分子生物学;亲环素A;综述;免疫抑制;前炎性因子;
KeyWord	Molecular Biology; Cyclophilin A; Review; Immunosuppression; Pro-inflammatory Factor
基金项目
页码	236-238

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引用本文

涂剑,严鹏科,廖端芳. 亲环素A生物学功能的研究进展 [J]. 中国动脉硬化杂志. 2005; ; (02). 236 - 238.

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