氨氯地平对ox-LDL诱导的人脐静脉内皮细胞MCP-1 mRNA表达的影响-CSCIED科技核心评价数据库-手机版

氨氯地平对ox-LDL诱导的人脐静脉内皮细胞MCP-1 mRNA表达的影响

Effect of Amlodipine on MCP-1 mRNA Expression in hUVEC-12 Induced by ox-LDL

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DOI
刊名	南华大学学报(医学版)
年，卷(期)	2009, 37(01)
作者	涂剑1徐丽梅2刘世远3韦知樱3涂玉林2,
作者单位	1.南华大学药理教研室2.南华大学心血管病研究所3.南华大学
摘要	论文观察氨氯地平对氧化型低密度脂蛋白(ox-LDL)诱导的人脐静脉内皮细胞(hUVEC-12)单核细胞趋化蛋白1(MCP-1)mRNA表达的影响,以进一步探讨氨氯地平抗动脉粥样硬化的作用机制。结果表明，筛选出ox-LDL与hUVEC-12共同孵育的合适浓度为50 mg/L,时间为24 h。氨氯地平可下调MCP-1 mR-NA的表达,并且对其表达的影响呈现浓度依赖性。
Abstract	The study investigated the effect of amlodipine on the expression of monocyte chemoattractant protein 1 (MCP-1) mRNA in human umbilical vein endothelial cells (hUVEC-12) induced by oxidized low-density lipoprotein (ox-LDL), aiming to further explore the mechanism of amlodipine in inhibiting atherosclerosis. The results demonstrated that the optimal concentration and duration for co-incubation of ox-LDL with hUVEC-12 were 50 mg/L and 24 hours, respectively. Amlodipine downregulated the expression of MCP-1 mRNA in a concentration-dependent manner.
关键词	氨氯地平;单核细胞趋化蛋白1;氧化型低密度脂蛋白;人脐静脉内皮细胞;
KeyWord	Amlodipine; monocytes chemotactic protein-1; oxidized low density lipoprotein; human umbilical vein endothelial cell
基金项目
页码	10-13

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引用本文

涂剑徐丽梅刘世远韦知樱涂玉林. 氨氯地平对ox-LDL诱导的人脐静脉内皮细胞MCP-1 mRNA表达的影响 [J]. 南华大学学报(医学版). 2009; 37; (01). 10 - 13.

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