Caveolin-1在氧化型低密度脂蛋白诱导的巨噬细胞荷脂过程中的表达-CSCIED科技核心评价数据库-手机版

Caveolin-1在氧化型低密度脂蛋白诱导的巨噬细胞荷脂过程中的表达

Expression of Caveolin-1 on Lipid-Loaded Macrophages Induced by Oxidized Low Density Lipoprotein

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DOI
刊名	南华大学学报(医学版)
年，卷(期)	2009, 37(04)
作者	涂剑1廖端芳1周志刚2曹轩1朱炳阳1涂玉林3,
作者单位	1.南华大学药物药理研究所2.南华大学第一附属医院3.南华大学心血管病研究所
摘要	论文观察了Caveolin-1在氧化型低密度脂蛋白(ox-LDL)诱导的巨噬细胞荷脂过程中的表达变化,进而分析Caveolin-1在巨噬源性泡沫细胞形成过程中的作用。结果表明，75 mg/L ox-LDL与RAW264.7细胞共同孵育48 h后,细胞内胆固醇酯/总胆固醇的比值上升至42.3%±5.9%,符合荷脂细胞特征。Caveolin-1的蛋白表达较0 h组明显减弱。
Abstract	The study examined the changes in the expression of Caveolin-1 during the lipid loading process of macrophages induced by oxidized low-density lipoprotein (ox-LDL) and further analyzed the role of Caveolin-1 in the formation of macrophage-derived foam cells. The results showed that after 48 hours of co-incubation with 75 mg/L ox-LDL, the ratio of cholesteryl ester to total cholesterol in RAW264.7 cells increased to 42.3% ± 5.9%, meeting the criteria for lipid-laden cells. The protein expression of Caveolin-1 was significantly reduced compared to the 0-hour group.
关键词	Caveolin-1;巨噬细胞;氧化型低密度脂蛋白;
KeyWord	Caveolin-1;macrophages;oxidized low density lipoprotein
基金项目
页码	390-392

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引用本文

涂剑廖端芳周志刚曹轩朱炳阳涂玉林. Caveolin-1在氧化型低密度脂蛋白诱导的巨噬细胞荷脂过程中的表达 [J]. 南华大学学报(医学版). 2009; 37; (04). 390 - 392.

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