TO901317促进人乳腺癌细胞凋亡的研究-CSCIED科技核心评价数据库-手机版

TO901317促进人乳腺癌细胞凋亡的研究

TO901317 induces the apoptosis of MCF-7 and MDA-MB-231 human breast cancer cells

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DOI
刊名	中国临床药理学与治疗学
年，卷(期)	2015, 20(12)
作者	涂剑1刘晓旺1丁维珂1余平1陆凯强1陈霄霄1陈雪艳1周志刚2,
作者单位	1.南华大学药物药理研究所湖南省分子靶标新药研究协同创新中心2.南华大学第一附属医院
摘要	论文研究了肝X受体激动剂TO901317对人乳腺癌细胞凋亡的影响。结果表明，随着TO901317处理浓度的增加和时间的延长,对细胞活力的抑制作用逐渐增强,凋亡现象逐渐明显。进一步通过Western blot检测发现,TO901317可下调Bcl-2蛋白表达,促使凋亡蛋白Bax和cleaved-Caspase 3表达增多,进一步证实TO901317促进两种乳腺癌细胞凋亡。
Abstract	The paper investigated the effects of the liver X receptor agonist TO901317 on apoptosis in human breast cancer cells. The results demonstrated that as the concentration of TO901317 increased and the treatment duration extended, its inhibitory effect on cell viability progressively intensified, and apoptosis became increasingly evident. Further Western blot analysis revealed that TO901317 downregulated the expression of Bcl-2 protein while upregulating the expression of the apoptotic proteins Bax and cleaved-Caspase 3. These findings further confirmed that TO901317 promotes apoptosis in both breast cancer cell lines.
关键词	TO901317;人乳腺癌细胞;细胞凋亡;
KeyWord	TO901317;human breast cancer cells;cell apoptosis
基金项目
页码	1340-1347

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引用本文

涂剑刘晓旺丁维珂余平陆凯强陈霄霄陈雪艳周志刚. TO901317促进人乳腺癌细胞凋亡的研究 [J]. 中国临床药理学与治疗学. 2015; 20; (12). 1340 - 1347.

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