T0901317通过上调LXRα表达促进人乳腺癌MDA-MB-231细胞凋亡-CSCIED科技核心评价数据库-手机版

T0901317通过上调LXRα表达促进人乳腺癌MDA-MB-231细胞凋亡

T0901317 induces apoptosis of human breast cancer MDA-MB-231 cells by up-regulating LXRα expression

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DOI
刊名	中国病理生理杂志
年，卷(期)	2016, 32(05)
作者	涂剑1陆凯强1丁维珂1刘晓旺1熊婷1刘伶1严欣1周志刚2,
作者单位	1.南华大学药物药理研究所2.南华大学第一附属医院
摘要	论文观察肝X受体(LXR)激动剂T0901317对人乳腺癌细胞MDA-MB-231凋亡的作用及其机制。结果表明，随着T0901317处理浓度的增加和时间的延长,凋亡现象逐渐明显。进一步通过Western blot检测发现,T0901317可下调Bcl-2蛋白表达,cleaved caspase-3表达增多,而LXRα的表达上调;RT-q PCR检测结果也显示,T0901317可下调Bcl-2 mRNA表达,而上调LXRα表达。
Abstract	The study investigated the effects of the liver X receptor (LXR) agonist T0901317 on apoptosis in human breast cancer cells MDA-MB-231 and its underlying mechanisms. The results demonstrated that as the concentration of T0901317 increased and the treatment duration extended, apoptosis became progressively more evident. Further Western blot analysis revealed that T0901317 downregulated the expression of the Bcl-2 protein, increased the expression of cleaved caspase-3, and upregulated the expression of LXRα. RT-qPCR results also showed that T0901317 downregulated the mRNA expression of Bcl-2 while upregulating the expression of LXRα.
关键词	T0901317;肝X受体α;MDA-MB-231细胞;细胞凋亡;
KeyWord	T0901317;Liver X receptor α;MDA-MB-231 cells;Apoptosis
基金项目
页码	836-840

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引用本文

涂剑陆凯强丁维珂刘晓旺熊婷刘伶严欣周志刚. T0901317通过上调LXRα表达促进人乳腺癌MDA-MB-231细胞凋亡 [J]. 中国病理生理杂志. 2016; 32; (05). 836 - 840.

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