TO901317经LXRα/NF-κB抑制MCF-7乳腺癌细胞迁移-CSCIED科技核心评价数据库-手机版

TO901317经LXRα/NF-κB抑制MCF-7乳腺癌细胞迁移

TO901317 inhibits the migration of MCF-7 breast cancer cells through LXRα/NF-κB

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DOI	10.19296/j.cnki.1008-2409.2024-01-010
刊名	华夏医学 ACTA MEDICINAE SINICA
年，卷(期)	2024, 37(01)
作者	涂剑1王彦翔1周志刚2杨萍3刘晓旺4余平4,
作者单位	1.桂林医学院药学院2.桂林医学院第二附属医院3.桂林医学院临床医学院4.南华大学药学院
摘要	论文探究肝X受体(LXR)激动剂TO901317对MCF-7人乳腺癌细胞迁移能力的作用及机制。结果表明，随着TO901317处理浓度的增加，MCF-7细胞的迁移能力明显得到抑制，差异具有统计学意义(P<0.05);同时LXRα与IκBα的表达逐渐增强，而NF-κB p65的表达则显著降低。LXRα siRNA可显著延缓TO901317的上述作用，PDTC处理则进一步增强TO901317对乳腺癌细胞迁移的抑制作用。
Abstract	The study investigated the effects of the liver X receptor (LXR) agonist TO901317 on the migration ability of MCF-7 human breast cancer cells and its underlying mechanisms. The results showed that, with increasing concentrations of TO901317 treatment, the migration ability of MCF-7 cells was significantly inhibited, and the difference was statistically significant (P < 0.05). Simultaneously, the expression of LXRα and IκBα gradually increased, while the expression of NF-κB p65 significantly decreased. LXRα siRNA notably delayed the aforementioned effects of TO901317, while PDTC treatment further enhanced the inhibitory effect of TO901317 on breast cancer cell migration.
关键词	TO901317，肝X受体α，核因子κB，MCF-7乳腺癌细胞，细胞迁移
KeyWord	TO901317, liver X receptor α, NF-κB, MCF-7 breast cancer cells, cell migration
基金项目
页码	69-74

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引用本文

涂剑王彦翔周志刚杨萍刘晓旺余平. TO901317经LXRα/NF-κB抑制MCF-7乳腺癌细胞迁移 [J]. 华夏医学. 2024; 37; (01). 69 - 74.

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